canadian glp 1 3 million Canadians use GLP-1 drugs. Survey says that's changing their appetites — and habits The expanding benefits of GLP-1

doi: 10.3389/fbioe.2023.1129768 Received 22 December 2022 Accepted 19 January 2023 Published 09 February 2023 Volume 11 - 2023 Edited by Xiaowei Zeng, Sun Yat-Sen University, China Reviewed by Xiaojun Xiao, Shenzhen University, China Chuangnian Zhang, Chinese Academy of Medical Sciences and Peking Union Medical College, China Updates Copyright 2023 Khakpour, Salehi, Naghib, Ghorbanzadeh and Zhang

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GLP-1RA is widely used as a treatment for T2D, and in addition to improving glycemic control, it has been suggested that it may act on multiple mechanisms related to the pathophysiology of AD, including neuroprotective, anti-inflammatory, and antioxidant effects

In general, GPX4 (glutathione peroxidase 4) is a typical member in GPx (total glutathione peroxidases) family and acts as an antioxidant protein with glutathione peroxidase activity to suppress phospholipid oxidation and ROS (reactive oxygen species) production to suppress ferroptosis 49,50,51,52

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If the presence of the MTHFR variant is suspected, they may stop the supplementation leading to a quick resolution